Bacterial toxins and the immune system
نویسنده
چکیده
Microorganisms that cause persistent infection often exhibit specific adaptations that allow them to avoid the adaptive immune response. Recently, several bacterial toxins have been shown in vitro to disrupt immune cell functions. However, it remains to be established whether these activities are relevant during infection and whether these toxins have specifically evolved to disrupt the adaptive immune system.
منابع مشابه
Bacterial toxins and the immune system: show me the in vivo targets
Microorganisms that cause persistent infection often exhibit specific adaptations that allow them to avoid the adaptive immune response. Recently, several bacterial toxins have been shown in vitro to disrupt immune cell functions. However, it remains to be established whether these activities are relevant during infection and whether these toxins have specifically evolved to disrupt the adaptiv...
متن کاملMultivalent bacterial inhibitor protects against toxins
Certain bacteria, such as enterohemorrhagic Escherichia coli O157:H7, are difficult to treat because destruction of the cells by standard antibiotics releases bacterial toxins. Pavel Kitov et al. have created a class of multivalent inhibitors that can bind and sequester such toxins through multiple, low-affinity interactions. The authors designed a polymer scaffold that aggregated the E. coli S...
متن کاملMultivalent bacterial inhibitor protects against toxins
Certain bacteria, such as enterohemorrhagic Escherichia coli O157:H7, are difficult to treat because destruction of the cells by standard antibiotics releases bacterial toxins. Pavel Kitov et al. have created a class of multivalent inhibitors that can bind and sequester such toxins through multiple, low-affinity interactions. The authors designed a polymer scaffold that aggregated the E. coli S...
متن کاملAB Toxins: A Paradigm Switch from Deadly to Desirable
To ensure their survival, a number of bacterial and plant species have evolved a common strategy to capture energy from other biological systems. Being imperfect pathogens, organisms synthesizing multi-subunit AB toxins are responsible for the mortality of millions of people and animals annually. Vaccination against these organisms and their toxins has proved rather ineffective in providing lon...
متن کاملIncorporating Amino Acids Composition and Functional Domains for Identifying Bacterial Toxin Proteins
Aside from pathogenesis, bacterial toxins also have been used for medical purpose such as drugs for cancer and immune diseases. Correctly identifying bacterial toxins and their types (endotoxins and exotoxins) has great impact on the cell biology study and therapy development. However, experimental methods for bacterial toxins identification are time-consuming and labor-intensive, implying an u...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 201 شماره
صفحات -
تاریخ انتشار 2005